Regeneration and repair are widespread phenomena in the biological kingdom, but the capacity varies among species.
Both amphibians and invertebrates can replace lost or damaged organs and tissues that are identical in structure and function to the original, regenerating a wide variety of tissues including spinal cords, limbs, hearts, eyes, and even parts of their brains.
In a similar fashion, many of these species possess fascinating skills for repairing and reversing cellular and genetic damage. Cancer, as an example, is found to be extremely rare in tissues of species displaying an efficient regenerative mechanism, even under the action of carcinogens. In many cases, when cancer does occur, tumors have been found to spontaneously remodel and integrate into their surroundings as normal, healthy tissue.
Unfortunately for humans, the situation is very different. In most instances, the structure or function of an organ will not be restored after tissue damage, and is often replaced by scarring. Additionally, while humans do possess robust DNA repair mechanisms, these capabilities are diminished substantially over time as we age.
Extensive study into the regeneration and repair mechanisms of non-human species have found them to be intricately connected to an underlying capability of complex tissue reprogramming and remodeling. These capabilities represent a biological regulatory state reset, whereby damage is erased in cells, followed by their redirection into a developmental program, where they become reintegrated with their micro-environment cellular neighbors, and reorganized via a community effect along tissue, organ and positional specificity.
While many of these species possess these reprogramming and remodeling capabilities throughout their lifetimes, the last and only time at which humans experience such potential is during the brief period following fertilization when egg and sperm first come together. And then it is gone.
Bioquark’s mission is to bring these capabilities back for therapeutic application in humans.